GLP‑1 and mental health: mood changes, anxiety, and what the research says

Introduction

The FDA found no increased risk of suicidal thoughts or behavior with GLP‑1 medicines in its January 13, 2026 safety review. Its review included evidence on semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound). Tell your clinician about new or worsening mood symptoms during treatment. [1]

The FDA findings and current warnings

The FDA reviewed 91 placebo-controlled trials with 107,910 participants, plus observational evidence. It found no increased risk of suicidal thoughts or behavior, or of the other psychiatric outcomes it examined, including anxiety and depression. It asked manufacturers to remove the suicidal behavior and ideation warning from Wegovy, Zepbound, and Saxenda labels. [1]

Current U.S. Wegovy and Zepbound prescribing information records removal of that warning. [5] [6] The FDA’s findings do not establish GLP‑1 medicines as treatments for depression or anxiety. Continue prescribed care and discuss treatment concerns with your clinician. [1]

Describe mood changes to your clinician

Note when a symptom started, how severe it feels, and how often it occurs. Include changes in sleep or interest in usual activities, and describe any effect on work or relationships. Ask for help even if you are unsure whether your injection caused a symptom. NIMH recommends describing symptoms and recent life changes to your healthcare provider. [7]

For a routine appointment, you could write: “I started avoiding calls from friends last week and have had trouble sleeping for three nights.” Add the dates of medication changes so your clinician has that context. Keep notes brief enough that you can use them during the visit.

Low blood sugar can resemble anxiety

Shakiness, sweating, irritability, or a fast heartbeat can occur with low blood sugar. Ozempic and Mounjaro labels warn of higher hypoglycemia risk when you use them with insulin or a sulfonylurea. [2] [3]

If you have symptoms of low blood sugar, check your glucose if you can and follow the treatment plan from your diabetes team. Severe hypoglycemia can cause seizures or loss of consciousness and needs treatment right away. Ask your team in advance how you and someone nearby should respond. [8]

Build support into your routine

NIMH recommends regular meals, enough sleep, physical activity, and contact with people you trust as part of mental-health self-care. These habits can support professional treatment. Ask for help if mood symptoms cause distress or interfere with daily activities. [4]

Choose a manageable step, such as setting aside time to talk with a friend or writing down a concern for your next appointment. You can also ask your clinician about sleep changes; our GLP‑1 and sleep guide can help you prepare those questions.

Prepare for a care appointment

Bring a list of prescriptions, over-the-counter medicines, and supplements, and review your family’s mental health history. NIMH also suggests preparing questions and considering a trusted friend or relative who can help you take notes. [7] Tell your provider about your own mental health history and any current care.

Ask who to contact between visits and how your prescriber and mental health clinician can coordinate follow-up. You could also ask: “Which changes should prompt a call before our next appointment?” Write down the contact details with the plan.

Get help for worsening mood or suicidal thoughts

Tell a healthcare professional about new or worsening depression, suicidal thoughts, or unusual changes in mood or behavior. Do not wait for a pattern in your log or a scheduled appointment if you feel unsafe. [1]

In the United States, call 988 or text 988 for crisis support. Call 911 in a life-threatening emergency. Outside the United States, contact your local crisis or emergency service. [4]

Track mood notes with Shotsy

For routine care, use Shotsy’s daily notes to record mood changes beside dose dates. Share the record with your clinician. Shotsy cannot assess suicide risk, diagnose a mental health condition, or replace crisis support.

Conclusion

Discuss new symptoms with your care team and use notes to support routine appointments. Seek help without waiting if your safety is at risk.